Buy Roszet (rosuvastatin and ezetimibe)

What is Roszet (rosuvastatin and ezetimibe) for?

Roszet (rosuvastatin and ezetimibe) is a combination of two medicines indicated in adults:

• As an adjunct to diet in patients with primary non-familial hyperlipidemia to reduce low-density lipoprotein cholesterol (LDL-C)
• Alone or as an adjunct to other LDL-C-lowering therapies in patients with homozygous familial hypercholesterolemia (HoFH) to reduce LDL-C

It is available in tablet form, containing either 5mg/10mg, 10mg/10mg, 20mg/10mg or 40mg/10mg rosuvastatin and ezetimibe, respectively.^[1]

How does Roszet (rosuvastatin and ezetimibe) work?

The active ingredients in Roszet are rosuvastatin and ezetimibe. Rosuvastatin is an HMG-CoA reductase inhibitor, also known as statin. Statins work by inhibiting the production of cholesterol in the liver by inhibiting the enzyme HMG-CoA reductase. This lowers the levels of LDL-C (bad cholesterol). Statins are the standard of care for people with high cholesterol.2,3

Ezetimibe is a cholesterol absorption inhibitor that works by preventing the absorption of cholesterol in the intestine. This way, less cholesterol can enter the blood from food and bile. Ezetimibe is often given together with a statin because they work in different ways, so the effects add up to further lower LDL-C.2,3

Where has Roszet (rosuvastatin and ezetimibe) been approved?

Roszet (rosuvastatin and ezetimibe) was approved for the treatment of diabetic people with severe hypoglycemia by:

• The Food and Drug Administration (FDA), USA on March 23, 2021.4

Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

How is Roszet (rosuvastatin and ezetimibe) taken?

The standard dosage range is:^[1]

• Tablets of 5 mg/10 mg to 40 mg/10 mg once daily, with or without food

Take this medicine exactly as prescribed. Keep taking Roszet unless your treating doctor tells you to stop. If you stop taking the tablets, your LDL-C levels may rise again.^[1]

Roszet may affect the way other medicines work, and other medicines may affect how Roszet works, so it is important that you inform your doctor about all medicines you take. Your dosage may need to be modified.^[1]

Roszet is contraindicated in patients with active liver disease or decompensated cirrhosis, and hypersensitivity to any ingredient of this product.^[1]

Complete information about Roszet (rosuvastatin and ezetimibe) dosage (modifications) and administration can be found in the official prescribing information listed in our references section.^[1]

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Roszet (rosuvastatin and ezetimibe)?

Common adverse reactions

The most common side effects ( ≥2% of adult and pediatric patients) listed in the prescribing information include:^[1]

• headache
• nausea
• muscle aches and pains
• weakness
• constipation
• common cold and flu
• diarrhea
• dizziness
• joint pain
• stomach pain
• runny nose and sore throat
• tiredness
• pain (back, hands, legs)

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include:^[1]

• muscle pain, tenderness and weakness (myopathy)
• allergic reactions
• liver problems

Use in a specific population

Roszet (rosuvastatin and ezetimibe) may harm a fetus. Discuss with your treating doctor if you are pregnant or may be pregnant, as Roszet treatment may need to be discontinued.^[1]

Breastfeeding is not recommended during treatment with Roszet.^[1]

Before starting with treatment, tell your doctor about all of your medical conditions and the medicines you are using.^[1]

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.^[1]

References

1. Full prescribing information [FDA]: Roszet (rosuvastatin and ezetimibe) [PDF]
Althera Life Sciences, Mar 2021

2. HMG-CoA Reductase Inhibitors
Healio, cited Sep 2021

3. Ezetimibe
Heartuk.org.uk, cited Sep 2021

4. FDA Approves Roszet (rosuvastatin and ezetimibe) to Reduce LDL-C in Hyperlipidemia and Homozygous Familial Hypercholesterolemia
Drugs.com, Mar 2021